Effect of recombinant human growth hormone on early activities of myocardial myeloperoxidase in rats with scalded injury

Objective To study the effect of recombinant human growth hormone（rhGH） on early activities of myocardial myeloperoxidase in rats with scald. Methods Sixty male Sprague-Dawley rats were randomly divided into control group and treatment group,30 in each group.A 30% TBSA III scald model was established.Rats in control group received fluid infusion after scald according to the formula of Parkland,and those in treatment group received fluid infusion with rhGH（3U/kg·d） subcutaneously injected 6h after scald.Serum cTnI level and myocardial myeloperoxidase activities in both groups were measured at 0,12,24,48,and 96h after scald. Results The serum cTnI level and myocardial myeloperoxidase activities were significantly higher in control group B at different time points after scald,especially 12h after scald（r=0.969,P＜0.01）.The same trends in serum cTnI level and myocardial myeloperoxidase activites was observed in treatment group.However,they were significantly higher than those in control group（P＜0.05）.Pathological examination showed that inflammatory cell infiltration and myocardial damage were severer in treatment group than in control group. Conclusion Focal myocarditis occurs in rats early after severe scald,and early use of rhGH can aggravate myocardial damage.