Therapeutic effect of photodynamic therapy on condylomata acuminata and its pathology

Objective To study the therapeutic effect of δ-amino-ketovaleric acid photodynamic therapy（δ-ALA-PDT） on condylomata acuminata and its pathologic changes before and after δ-ALA-PDT. Methods Sixty patients with condylomata acuminata were randomly divided into δ-ALA-PDT group,CO2 laser therapy group,and combined δ-ALA-PDT and CO2 laser therapy group.Recurrence of condylomata acuminata and adverse reactions were recorded.Patients in δ-ALA-PDT group received histopathology examination and their inflammation was compared before and after treatment. Results The recurrence rate of condylomata acuminata in 3 groups was 20%,55% and 10%,respectively（P＜0.05）.The recurrence rate of condylomata acuminata in combined δ-ALA-PDT group and CO2 laser therapy group was the lowest,indicating that the effect of combined δ-ALA-PDT and CO2 laser therapy on condylomata acuminata was the best,followed by δ-ALA-PDT and CO2 laser therapy.The incidence of adverse reactions was the lower in δ-ALA-PDT group than in the other two groups（P＜0.05）.The number of inflammatory cells was significantly less after δ-ALA-PDT than before δ-ALA-PDT（P＜0.05）.The inflammation reaction was severer after δ-ALA-PDT than before δ-ALA-PDT. Conclusion δ-ALA-PDT can significantly reduce the recurrence of condylomata acuminata and is a safe and well-tolerated therapy for condylomata acuminata.