Adult Langerhans cell histiocytosis: A report of 3 cases and literature review

Objective To study the clinical manifestations,pathologic characteristics,treatment and prognosis of adult Langerhans cell histiocytosis（LCH）. Methods Three adult LCH patients were retrospectively analyzed with related literature reviewed. Results The 3 LCH patients were a female at the age of 39 years,a male at the age of 36 years,and a female at the age of 56 years with their pubis（1/3）,iliac（1/3）,frontal bone（1/3）,thigh bone（1/3）,ribs（1/3）,skin（1/3）,lymph nodes（1/3） involved.Immunohistochemistry was positive for CD1a and S-100.After combined chemotherapy,2 patients achieved complete remission and the other patient with multiple systems involved had a poor response and needed further treatment and observation. Conclusion Adult LCH is a rare disease with various clinical manifestations.It is easy to be misdiagnosed and missed,and should be treated according to the condition of each patient.