Selection of pregnant time in patients with systemic lupus erythematosus and their pregnant outcome

Objective To study the correlation between selection of pregnant time in patients with systemic lupus erythematosus（SLE） and their pregnant outcome. Methods Clinical data about 33 pregnant SLE patients admitted to our hospital from January 2005 to July 2011 were retrospectively analyzed.The patients were randomly divided into persistent SLE remission group（Group A,n=20） and active SLE group（Group B,n=13） according to their pregnant time.Complications and pregnant outcomes were compared between the two groups. Results Severe complications occurred in 6（30%） out of the 20 patients in group A,with full-term delivery,premature delivery,therapeutic abortion,and fetal death in 10,7,2,and 1 patients respectively,no death of pregnant and parturient women,and no deformity of neonates.Severe complications occurred in 11（84.6%） out of the 13 patients in group B,with premature delivery,therapeutic abortion,and fetal death in 8,3 and 2 patients respectively.The incidence of complications,the fetal loss and the premature delivery rate were significantly higher while the body weight of neonates was significantly lower in group B than in group A（P＜0.05）. Conclusion SLE patients should have pregnancy when their SLE is stable.Careful monitoring,rational use of drugs,and termination of pregnancy are the keys to decreasing the incidence of complications during pregnancy and improving the outcomes of both mothers and infants.