First case of unrelated donor allogeneic peripheral blood stem cell transplantation in the treatment of severe aplastic anemia in China

Objective: To investigate efficacy of unrelated donor allogeneic peripheral blood stem cell transplantation（UD-PBSCT） in treatment of severe aplastic anemia（SAA）.Methods: A 21-year-old Chinese woman had been suffering from SAA for 6 years.We did not find any HLAmatched related donor for the patient.The patient was treated with PBSCT from a HLA-A-1-allele-mismatched unrelated donor with cyclophosphamide,etoposide and antithymocyte globulin for conditioning.Mycophenolate mofetil,cyclosporin A,CD25 antibody and short-term methotraxate were administered as graft versus host disease（GVHD） prophylaxis.Results: The absolute neutrophil count of 0.998 ×10⁹/L was achieved at 22^nd day,the platelet count ≥20 ×10⁹/L at 33^rdday,the platelet counted to 52×10⁹/L at 50^thday,the hemoglobin counted to 104g/L at 61^st day.Disease-free survival without GVHD was 8 months.Conclusion: UD-PBSCT may be considered as a choice when hematopoietic stem cell transplantation is needed for SAA patients.