Human peripkerial T cell proliferation induced by superantigen SEB

Our study focused on extrathymic differentiation of T cells.Staphylococcal enterotoxins B（SEB）,as one kind of superantigen,was used and induced massive proliferation of human peripherialblood T cells.Adherent cells in lymphocytes,rather than non-adherent cells,also played an importantantigen presenting role during T cells proliferation,After SEB-stimulating,IL-2 were released andpopulation increase from 27%to 41%.They were differentiated from population. Theresults showed that superantigen SEB may up-regulate the response reaction of T cells in periphe-rial blood lymphocytes and the proliferation of Tcells may be involved to extrathymic differentia-tion of T cells.To study mechanism of T cells differentiation will give us new means to fight disease,and theknowledge about T-cell activation will help us to modulate the immune system in new ways.