Expression of ER, PR and Her-2 in primary breast cancer and its recurrent foci

Objective To investigate the expression of ER, PR and Her-2 in primary breast cancer and its recurrent foci. Methods Changes in expression of ER, PR and Her-2 in primary breast cancer and its recurrence foci of 60 patients were detected and their relation was analyzed. Results The positive expression rate of ER and PR was 61.67% and 56.67%, respectively, in primary breast cancer, and 41.67% and 36.67%, respectively, in its recurrent foci（P＜0.05）. The positive expression rate of Her-2 was 18.33% in primary breast cancer and 40.00% in its recurrent foci（P＜0.05）. The positive expression rate of ER and PR was lower than that of Her-2 in recurrent foci of breast cancer（P＜0.05）. Conclusion The expression of ER, PR and Her-2 is significantly different in primary breast cancer and its recurrent foci. The expression of Her-2 is negatively related with that of ER and PR in recurrent foci of breast cancer.