Serum TXB₂ and 6-K-PGF_1αdeterminationd and their clinical significance in patients with unstable angina

In order to search the role of platelet-induced coronary vasospasm on the pathogenesis of uns-table angina,serum TXB₂ and 6-K-PGF_1α levels were estimated in 58 hospitalized aged patients.Among them,14 cases were unstable angina （group 1）.The results showed that only in group 1the mean values of serum TXB₂ （mean±SD） were significantly higher during angina attacks thanthose of symptomfree period （399.49±390.27 vs 85.64±82.26 pg/ml,P＜0,05）.it was also truewhen group 1 was compared with healthy persons （399.49±390.27 vs 127.0±48.0 pg/ml,p＜0.05）.The mean values of serum 6-K-PGF_1α revealed no apparent change.The authors conclud-ed that serum TXB₂ concentrations elevated only during the attacks of unstable angina may suppo-rt the hypothesis that the pathophysiological change of unstable angina is mainly due to a regionalsudden decrease of coronary blood flow induced by TXB₂ promoted vasosoasm.Then,three kindsof drug are recommended for relieving the ischemic cardiac pain.They are small dose of aspirin（300mg/day）,nitroglycerin（1-2mg VD/day for 10 days）,and nifedipine （10mg 3—4 i.d.）or diltia-zero （30mg 3—4 i.d.）.