The effects of curcumin on platelet aggregation and thrombosls in rat

Curcumin is the yellow pigment extract from Curcuma longa.The present study investigated its inhibiting effects on rat platelets.The result showed that curcumin exhihited significant.antiaggregation effect on rat platelets in vitro with IC50 62.56μmol/L.When given intraperitioneally,the aggregation rate of rat platelet induced by ADP was reduced 37.62 percent and the in vivo thrombosis was 60.31 percent inhibited.The results indicated that curcumin has an anti-platelet-aggregation effect In rat hoth in vitro and In vivo.