Value of ¹⁸F-FDG positron emission tomography/computed tomography in staging of diffuse large B-cell lymphoma

Objective To evaluate the value of positron emission tomography/computed tomography（PET/CT） and CT in staging of diffuse large B-cell lymphoma（DLBCL）. Methods Thirty-two patients with diffuse large B-cell non Hodgkin lymphoma were prospectively evaluated.All the patients who underwent a whole body ¹⁸F-FDG-PET/CT and CT（chest,abdomen and cavitas pelvis） were studied before therapy.The maximal standardized uptake value（SUVmax） of each single lesion and the SUV_max of mediastinal blood pool were measured and used to calculate the median T/MB value（tumor SUV/mediastinal SUV） of each patient. Results ¹⁸FFDG-PET/CT and CT were concordant in 70.6% lesions.The sensitivity,specificity,positive and negative predictive value,and the accurate rate of ¹⁸F-FDG-PET/CT was 100%,96%,99.7%,100% and 99.7%,respectively,which were much higher than those of CT（75.8%,4%,91.5%,1.2% and 70.9%）. Conclusion ¹⁸F-FDG-PET/CT is more sensitive and specific than CT for DLBCL,especially for organs except for lymph nodes.