Comparing the influence of the different resuscitative fluids on the degree of acute lung injury following hemorrhage

Objective: To test the hypothesis that different resuscitative fluids may immediately affect the degree of acute lung injury following hemorrhage,and to provide the scientific basis for the perfect fluid treatment in hemorrhage. Methods: Comparing the cytokine concentration in plasmas,lung permeability index and morphologic appearance of SD rats with different fluids after hemorrhage and resuscitation. Results: Resuscitation with LR solution resulted in a significant elevation of TNFαand IL-6level in plasma and significant morphologic appearance.Concentration of protein in BAL fluid was more significantly increased in the groups resuscitated with colloid than in LR group. Conclusion: 1.Different resuscitative fluids resulted in different degrees of acute lung injury after hemorrhage.TNFαand IL-6were the chief cytokines mediating the early lung injury.2.Significant hemodilution was observed in colloid groups and it benef-i cially influenced the lung injury,but resuscitation with colloid increased the egress of protein,and this adversely influenced the lung injury.