Diagnosis and treatment of malignant gastrointestinal stromal tumors

Objective: To investigate the clinical feature of the malignant gastrointestinal stromal tumors.Methods: The clinical data of 35 patients with malignant gastrointestinal stromal tumors of our hospital from 1998 to 2005 was reviewed.Results: 91.4% of the malignant gastrointestinal stromal tumors were originated from the stomach.Male female ratio was 1.9 to 1.Age range was from 13 to 82.The clinical manifestations of this group had no specificities.Abdominal sonography,computed tomography（CT）,GI X-ray series and endoscopy were used to detect the lesions before operation,the final diagnosis rate of the ultrasonic endoscope（75%） was higher than that of any other method.Abdominal sonography could not make a definite diagnosis.Surgical resections were performed in all the patients.Imatinib mesylate was the adjunctive therapy drug after operation.Immunohistochemical results showed that the positive rate of CD34 antigen（90%） and CD117 antigen（80%） were more than those of oher antigens（P＜0.05）.Post-operation recurrence rate was 44%,and post-operation five-year-survival rate was 32%.Conclusion: The prognosis of this disease is poor,so it is important to understand the disease,to discover and treat timely and to recheck regularly after operation.