An experimental study of medical glue in treating partial growth plate closure

Objective: To examine whether medical clue was able to prevent the recurrence of physeal bridge after operation. Methods: Based on a rabbit model, 28 white New-Zealand rabbits, 56 legs,were used and divided into four groups randomly. In Group A, the femoral condyle was exposed, but no defect was created; in Group B, a defect was created but left unfilled; autologous fat and N-butyl cyanoacrylate were placed in the defect in Group C and D.20 rabbits were radiographed weekly, and sacrificed 16 weeks after the operation,femora were removed, examined grossly and radiographed. Another 8 rabbits were killed at 5 weeks and 10 weeks, and histological, histochemical examinations were performed. Results: Compared with Group B, both autologous fat and medical glue can be used as interposition materials to make the femur grow longer and reduce the valgus deformity of knee joint, but N-butyl cyanoacrylate is more effective. Conclusion: None of the interposition materials, however, allow for completely normal growth. but N-butyl cyanoacrylate is a good choice to be used as the interposition material.