Therapeutic effectiveness of atorvastatin on chronic pulmonary heart disease in smokers

Objective To evaluate the effect of atorvastatin on pulmonary function in smokers with chronic pulmonary heart disease. Methods Fifty-five smokers with chronic obstructive pulmonary disease（COPD） complicated by chronic pulmonary heart disease were randomly divided into atorvastatin treatment group（n=27） and routine treatment group（n=28）.Patients in routine treatment were routinely treated and patients in atorvastatin treatment were treated with atorvastatin（20mg/d）.Changes in 6-minute walking test（6MWT）,pulmonary function and ultrasound cardiogram were observed before and after 6 months of treatment. Results The pulmonary arterial pressure was significantly lower,the 6MWT value was significantly higher,and the pulmonary function indexes including FEV₁ and FEV₁/FVC were much better in atorvastatin treatment group than in routine treatment group 6 months after treatment compared to 6 months before treatment（P＜0.05）. Conclusion Atorvastatin can effectively improve the life quality,pulmonary function and pulmonary arterial pressure of smokers with chronic pulmonary heart disease.