Diagnosis and therapyof sarcoidosis

Objective: To explore the clinical features, diagnosis and therapy of sarcoidosis. Methods: Clinical symptoms, pathological features and treatment of 25 patients with sarcoidosis were analysised. Results: 60% of sarcoidosis cases were over age 50. The main clinical manifestations of sarcoidosis included bilateral hilar and mediastinal lymphadenopathy （88%）、 skin lesions （36%）、swelling of superficial lymph nodes（16%）、hepatosplenomegaly （12%）、joint pains （8%）、ocular lesions（4%）. Chest radiographic abnormality rate is 100%, pulmonary function abnormality rate is 70%, SACEincreasing rateis 64%, negative reaction rate of PPD test is 74%.Amongpathological examination, definitive diagnosis rate of skin nodes biopsy is 83%,definitive diagnosis rate ofbiopsies of periphery lymph nodes is 75%, definitive diagnosis rate of TBLB is 64%,definitive diagnosis rate of BMBis 38%. Misdiagnosis rate is 28%. Conclusion: The morbidity of sarcoidosis increases in middle-old age patients. Sarcoidosis is a multiorgan involvement disease. Nonspecific constitutional symptoms may occur in the cases of sarcoidosis.TBLB and BMB are the convenient methods with highly definitive diagnosis rateand less invasive values in clinical practice.Oral corticosteroids is the most important method of treatment in patients of above-stageⅡor progressive loss oflung functions. Oral corticosteroids still had effect for recurrent patients. The key indication of treatment are assessing extent and severity of organ involvement, and evaluating whether the disease is likely to progress.