Hyperthyroidism in pregnancy:Clinical analysis of 32 cases

Objective: To investigate the effects of hyperthyroidism on the outcome,complications of pregnancies and the infants.Methods: Retrospective study was performed on the clinical data of 32 pregnant women with hyperthyroidism between 1994 and 2005 in PLA General Hospital.The patients were divided into two groups according to different serum TSH and FT₄ levels: well-controlled group and under-controlled group.Other 302 cases of normal pregnancies were chosen as the normal control.Results: The hyperthyroidism during pregnancy occurred in 0.47% of all women with pregnancy.And all the 32 cases were received ATD therapy,and 93.33%（14/15） patients treated with PTU.The incidence of the premature delivery,fetal distress,fatal death and low birth weight infant in under-controlled group were significantly greater than that in well-controlled group（P＜0.05）.However,the incidence of the pregnancy-induced hypertension syndrome（PIH）,placental abruption,and heart failure were lower in well-controlled group.Conclusion: It is vital for pregnant women with hyperthyroidism to well control the hyperthyroidism,so as to improve the outcomes of mothers and neonates.