The pair-matched crossover study of the effects of the trimetazidine on the ventricular arrhythmia in old myocardial infarcted cases

Objective: For further comprehending the effects of the trimetazidine on the ventricular arrhythmia in old myocardial infarction patients Methods: total 58 cases （29 pairs） of coronary heart disease/old myocardial infarction patients/OMI were studied;the major matching limitations are: age,sex,infarcted section,infarcted time,hypertension or not （the grade）,diabetes or not The study is randomized,pair matched,cross over and single blinded clinic study,the statistic analysis of variance （ANOV） was used Results: the incidence of ventricular arrhythmia was remarkably decreased in statistic difference（P＜0.005）after be treated by trimetazidine;and also decreased the incidence of the ventricular arrhythmia in activitiesperiod（P＜0.005）;For more severe ventricular arrhythmia （above the grade Lown3）,the using of trimetazidine also showed more significant positive effects（P ≈ 0.01） Conclusion: for the ventricular arrhythmia accompany with OMI,in addition to the routine treatment,the trimetazidine could also play an important role,with the usage decreasing of other anti arrhythmia drugs