Effect of a long-term administering of low dosage La（NO₃）₃ on insulin in serum and hepatocyte glycogen in rat

Objective:To investigate the long-term effects of low dosage La（NO₃）₃ on insulin and blood glucose in serum and hepatocyte glycogen in rat.Methods:Levels of Insulin and blood glucose and hepatocyte glycogen in rat were measured by radiommunoassay and microscopy image analysis system after administrated with La（NO₃）₃（10.0 mg/kg、 2.0 mg/kg、 0.2 mg/kg、 0.1 mg/kg）for six and seven months.Results:Having taken La（NO₃）₃ for 6 months,insulin levels in the 10.0 mg/kg group were reduced,blood glucose and hepatocyte glycogen levels in the 10.0 mg/kg group were increased,both in the sera of female and male rats;insulin levels、 blood glucose levels and hepatocyte glycogen levels in the 0.1 mg/kg、 0.2 mg/kg、 2.0mg/kg group,low dose treated groups was increased and later was reduced in the sera of the male.After fed by normal chow without La（NO₃）₃ for one month,the levels of insulin、 blood glucose and hepatocyte glycogen returned to normal again.Conclusion:A long-term low dosage La（NO₃）₃ could change insulin、 blood glucose and hepatocyte glycogen levels.Insulin、 blood glucose and hepatocyte glycogen levels could back to normal levels after a short time of feeding without La.La（NO₃）₃.In concentration of 0.2 mg/kg and 0.1 mg/kg,it had the capacity to increase the levels of insulin、 blood glucose and hepatocyte glycogen.