The Concentration of Atrial Natriurebic Factor in the Mammillary Bodies and the Median Eminence of Experimental and Spontaneous Hypertensive and Cerebral Hemorrhaged Rabs

The mammillary body, a pair of hemispheric tissue located at the base of brain behind hypothalamus, was known to have abundant vessels and ample supply of blood. Recently Atrial Natriuretic Factor （ANF）, a peytide involoved into the central regulation on blood pressure, was reported. It was also noticed that there were many ANF immunoreactive neurons in the medial nucleus of mammillary body （MB）. but upto now few report dealing with the ANF concentration and its change under pathological status was ever published. The content of ANF in MBs of rats from 3 experimental groups namely, hemorrhegd and contral SHR, and Winstar rats, were measured. The concentration of ANF was revealed the much higher in SHR with cerebral hemorrhage than contral （93.98 pg/mg vs 68.82pg/mg, p0.05） and Wistar （30.09pg/mg）. However no significant difference was detected among the ANF levels in median eminences of the three groups. Judged from present study, therefore, the ANF in MB was believed to be relcassed into circulation to regulate in certain way the blood preessure, and salt in diet might affect the concentration; while the ANF in median eminence was probably involved mainly in the regulation of pituitary function.