Two cases of male pseudohermaphroditism

Two cases of phenotype female, sex chromosome 46 XY, male pseudohermaphroditism were reported. Case 1, aged twenty-one, completely testicularly feminized. The testes in the bilateral hernial sacs have been removed. Histologic sections of the testes revealed dysgenesis of the seminiferous tubules wothout spermatogenesis. Case 2, aged twenty-three, suffered from simple gonadal dysgenesis, the pelvic mass of which has been operated on. Microacopic examination revealed bilateral gonadoblastomas, and the left, mixture of dysgerminoma, endodermal sinus tumor, choriocarcinoma and teratoma Laboratory examination revealed low estradiol. The serum testosterone in case 2 was higher than that of case 1, and this may possibly be related to the abnormal endocrinology of the gonadal malignant tumors. The diagnosis of gonad dysgenesis is usually not difficult,and we think that removal of gonad with dysgenesis should be done in the earlier stage for dysgenetic tumors may arise in individuals who have streaked gonad containing Y chromosome.