Graft-Versus-host Disease After Hematopoietic Stem Cell Transplantation

Graft-versus-host disease （GVHD） is one of the major complications in allo-BMT and is also reported in other types of hematopoietic stem cell transplantation. In 14 patients treated with allo-BMT, 7 patients （50％） were complicated by acute GVHD （grade Ⅳ: 2 cases, grade Ⅰ-Ⅱ: 5 cases） and 2 patients were complicated by chronic GVHD. One patient with grade Ⅰ GVHD in 9 cases treated with fetal liver transplantation was observed. One patient developed acute GVHD following infusion of non-irradiated allo-blood after ABMT. From Jan. 1988 to DEC. 1991, 57 patients treated with alIo-BMT had been reported in our country. The incidence of acute GVHD was 77.19% （grade Ⅲ-Ⅳ: 12 cases in 44 cases, 24.56%） and that of chronic GVHD was 24.56%. The result showed that the incidence of GVHD in our country was similar to that reported early in Europe. Otherwise, prevention and treatment of GVHD were also discussed in this paper.