The effects of ceftriaxone and amikacin on the immune response in rats pneumo-nia model

Forty Wistar rats were randomly divided into 4 groups.Thirty rats were infected with pneumoniaeKlebiella species by the intratracheal peroral routs,Ceftriaxone（CRO）and amikacin（AMK）were adiminis-tered at therapeutic doses intraperitoneally for 7 days and several immunologic parameters were measured.The results showed: （1）The weight of organs（thymus and spleen） and B cell density in the germinal centreof splenic follicles had no significant alteration in each groups;（2）CRO enhanced the chemoluminescenceplateau of polymorphonuclear leukocytes;（3）CRO increased the ACP activity,AMK decreased the phagocyto-sis and ADCC;（4）AMK decreased the number of CD and CD Tcells The resuIts indicated that CRO andAMK could advance or restrain the immune response in pneumonic rats,respectively.