EFFECTS OF BY-701 ON MEMORY

BY-701 is an undescribed piperidine derivative,substituted by two pheuyl groups in position 4.It’s chemical name is L-tertiary butyl-44-diphenylpiperidine-hydrochloride. BY-701 has anticholinergic property.The influences of BY-701 on memory behavior hippocampal electrical activity and acetylcholine content in animals were studied.The evaluation of memory deficits was based on the following:（1）percentage of conditioned passive avoidance reaction（CAR）,（2）mean response time,（3）mean ability to perform correcty 5 successive times in 10 trials,（4）mean number of trials to correcty to perform trials.It was found that BY-701 influences unconsolidated memory（a three day training period） more than consolideted memory （a 6 day training period）.It was also observed that the mnemoria effect of BY-701 was associated with ECoG changes and cholinergic reduced in hippocampas.These findings suggested that the chronic administration of BY-701 raises the possibility of impairing the ability of patients with Parkinson’s disease,particularly elderly ones,to learn new materials and to store or acquire new information into long-term memory.