To explore the gene modified strategy for stem cells directional differentiation by the glucose-steadied regulation

Objective: To investigate the strategy of gene modified for stem cells directional differentiation by the glucose-steadied regulation.Methods: 1.The expression of STAT-3（signal transducer and activators of transcription,STATs） protein and cells differentiation in the ARIP etc.cells were studied by gene modified and differentiation induced;2.Cells differentiation was studied by the expression of KUZ mRNA in the mouse pancreas islet cells after differentiation inhibited.Results: There was strong positive of immunofluorescence in ARIP cells after infected by Adenovirus assisted STAT-3 gene.Non-radioactivity in situ hybridization studies on the expression of Kuzbanian（KUZ） gene in trans-gene mice pancreas islet were positive.Conclusion: Gene modified induced by factor differentiation may be an availability approach of stem cells directional differentiation about the glucose-steadied regulation.