The development of multiple organ failure MOF in severe emergency patients——A clinical analysis of 84 cases

Eighty four cases of MOF which developed in emergency patienls were sorted out as: 38 cases due to infectious shock（IS）; 30, coronary heart disease （CHD） or cot pulmonle （CP）; 10, post operative shock （POS） and 6, posthemorrhagic shock （PHS）. The mean happening time （MHT） of MOF in IS （2,7 days） and POS （1.8 days） was earlier than that in MHT of POS （8.5 days）. The earliest failure organ （EFO） in IS was lung mostly, as where in PHS, POS EFO was liver, in CHD CP were heart and lung. The highest death rate was in OHD （91.6%）. The mechanism of MOF was studied on the basis of cellular and subcellular investigation (the injury to receptors of enzyme system, the loss of membranous stability, the increase in Ca⁺⁺ influx and the production of free radicals). For the prevention and early treatment of MOF clinical and laboratory monitorings were emphasized. Therapeutic measures including the stabilization of internal circumstances, to elevate organs’ perfusion, the improvemnt of blood rheology, lessening of pulmonary load, access of respiration, increase in cardiac output and renal blood flows, ablition of infectious foci and general nutrional support and drugs to protect the mitochondrial functions should be taken.