CD28 molecular expression and autoimmunity in human peripheral blood T cells activation by SEB

Objective: We examined the characteristics of human peripheral blood T cells activation by superantigen B（SEB）, and try to know if the proliferous T cells are as same as entrothymic T cells.Methods: We analyzed CD4, CD8, CD16 and CD28 molecular expression and autoimmunity of proliferous T cells by flow cytometry and cell culture. Results: Most of CD4⁺ T cells expressed CD28 molecular The CD4⁺CD8⁺T cells are different from extrothymic T cells. The dependence for T cells to APC exhibited decrease and showed autoimmunity against to isogenous antigen. Conclusion: The function of CD4⁺T cells activation in peripheral blood are different from the function of extrothymic T cells.