Preliminary research of cellular cardiomyoplasty

Objective: Patients with diffuse ischemic disease or end stage heart failure may not be appropriate candidates for there procedures. Celluar cardiomyoplasty （CCM）, a technique in which immature cells are transplanted into injured myocardium, has been proposed as a method to restore functional tissue in areas of chronic myocardial ischemia. Methods: Colloid gold method was used to label the cardiomyocytes in cultue. Cultured myocytes carrying colloid gold grains were transplanted into the myocardial tissue of dogs. At 6.12.36 days after transplantation, the animals were killed. Results: on day 12, immunorejection appeared in recipient animal heart, on day 36, no transplanted cells survived. Conclusions:Cellular cardiomyoplasty, a technique in which immature cells are transplanted into injured chronic myocardial ischemia.