Effect of breviscapine on biochemistry in hepatic ischemia-reperfusion injury

Objective:To explor the role of breviscapine （Bre） on dynamic changes of lipid peroxidation in hepatic ischemia-reperfusion injury（HIRI）.Methods:The HIRI model was used.Thirty-two rabbits were randomly divided into control group（（n=8））,model group（n=8）,Bre（5mg） group（n=8） and Bre（7mg） group（n=8）.The superoxide dismutase（SOD） activity,malondialdehyde（MDA） content,glutathione peroxidase（GSHPX） and alanine aminotransferase（ALT） activity in serum were observed before ischemia and at ischemia 45 min,reperfusion 30min,reperfusion 60 min.Results:The SOD activity,GSH-PX activity MDA,content and ALT activity of Bre group,as compared with model group,showed significant differences（（P＜0.05） or P＜0.01） at total time points of reperfusion.Conclusion:Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.