Analysis of plasma high-density lipoprotein level and its influence factors in patients with coronary heart disease

Objective: To analyze the distribution characteristics of high-density lipoprotein（HDL）and its particle subspecies in patients with coronary heart disease（CHD）and their influential factor. Methods: HDL subfractions were isolated from randomly selected 291 patients undergoing coronary angiography with the PEG-20000 precipitation method. Results: The plasma HDL levels were significantly lower in CHD patients and diabetic patients complicated by CHD than in normal subjects and CHD patients not complicated by type 2 diabetes,respectively.HDL cholesterol and HDL₂ were statistically increased in CHD patients treated with lipid-modifying drugs,while HDL₃ was not significantly changed. Conclusion: Plasma HDL₃ and HDL levels are negatively related with CHD.Diabetic factor can change the levels of HDL-C and its subspecies.