Co-expression of PrPc and p-Akt in gastric cancer and its clinical significance

Objective To study the expression of PrPc and p-Akt in gastric cancer tissue and its clinical significance. Methods Expressions of PrPc and p-Akt in gastric cancer tissue and its adjacent tissue were detected by immunohistochemistry. Results The positive expression rate of PrPc and p-Akt was 82.4%（66/85） and 88.2%（75/85）,respectively,in 85 gastric cancer patients,which was significantly higher than that in its adjacent tissue（r=0.514,P＜0.05）.The expression levels of PrPc and p-Akt were significantly correlated with the down-regulated differentiation of gastric cancer cells and up-regulated expression of PrPc and p-Akt in gastric cancer tissue（P＜0.05）. Conclusion PrPc and p-Akt are synergistically expressed in gastric cancer tissue,and p-Akt may play a role in PrPc-induced malignant phenotype of gastric cancer.