Changes of peripheral dendritic cells in chronic hepatitis B patients treated with CINF

Objectives: To observe the changes of peripheral dendritic cells subsets consecutively in patients with chronic hepatitis B during Consensus Interferon（CIFN） treatment.Methods: Twenty-three patients with chronic hepatitis B were treated with CIFN for 24 weeks and followed up for another 24 weeks.After CIFN withdrawal,During CIFN treatment peripheral dendritic cell subsets were measured.Results: After CIFN treatment,43.5% patients obtained virological and biochemical responses.The percentage and absolute number of peripheral type I and Ⅱdendritic cells decreased greatly（All P＜0.05）.Conclusions:Consistent virological and biochemical response can be obtained in some patients with chronic hepatitis B virus infection after CIFN treatment,and the percentage and number of peripheral type I and Ⅱdendritic cells are greatly decreased too.