Studies of ischemic cerebral stroke model

In 477 of Sprague-Dawley （SD） and wistar rats, ischemic cerebral stroke model （ICSM） was made to observe the effects of strains, anesthetic agents, age, sex, time intervals of bilateral common carotid artery （CCA） ligation （BCCAL） and unilateral CCA ligation on ischemic cerebral stroke （ICS）. The results showed that accidents of ICS were affected by strains, anesthetic agents, age, time intervals of BCCAL, but not by sex. The ICSM was ideal because SD or Wistar rats were cheap and easily available, and the procedure was simple and easy, with 16-77% of animals saffering from some symptoms and signs, and 12-73% survival, Thus, different ICSM for different purpose of research can be made by the way of simultaneous BCCAL or BCCAL at different intervals in aduit SD or wistar rats of random sex.