Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal poly

Objective: The purpose is to study the effect of IgE、GM-CSF to eosinophil accumulation in the nasal polyps and find the relationship between IgE and GM-CSF.Methods: Thirty mucosa constitution samples of nasal polyps and eleven inferior nasal concha were observed.The concentration of IgE and GM-CSF was measured with ELISA techique in homogenized polyp tissue and in control mucosa,and the number of eosinophils were counted in the same tissues.Results: The statistical analysis showed that the level of IgE、GM-CSF and eosinophils have significant different between the nasal polyps and control group（（P＜0.01））.There was positive correlation between IgE/GM-CSF and the number of eosinophils in the nasal polyps group（（r=0.68）,r=0.62,P＜0.01）.The correlation between concenstration of IgE and GM-CSF was also significant in nasal polyps group（r=0.54,P＜0.01）.Conlusion:Nasal polyps is characterized by eosinophil accumulation.IgE and GM-CSF may be contributed to the recruitment of eosinophils in nasal polyps.Type-1 allergy mediated by IgE played an important role in the pathogenesis of nasal polyps.