Influence of using lamivudine on therapeutic efficacy of entecavir in chronic hepatitis B patients on adefovir therapy

Objective To evaluate the influence of using lamivudine on therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy. Methods Papers in Chinese and English（published before May,2010） on the therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy were searched.A meta-analysis was performed for the papers that were divided into different groups according to the history of using lamivudine and the serum HBV DNA level,with the relative risk calculated as the therapeutic efficacy. Results Only 2 English papers were included.The average relative risk was 0.52 and the confidence interval was 0.29-0.93. Conclusion The history of using lamivudine reduces the therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy.