The changes in hepatic structure and function following hydrofluoric acid burns

Objective: To study the changes of hepatic structure and function in rats with hydrofluoric acid burned injury.Methods: Wistar rats were randomly divided into four groups,including group A,B,C and D.The rats of group A and B were received 6% third degree burned injury on the back with hydrofluoric acid or hot water respectively,and those of group C were received 30% TBSA third degree burned injury with hot water.Blood sampling were carried out at 5 hrs,10hrs and 24hrs post burns for examinations of ALT,AST and LDH.The hepatic ultrastructure was investigated with supermicroscope.Results: The levels of serum ALT and AST in rats of group A were significantly increased than that of others（P＜0.01）and the parameter of group C were notably higher than that of group B and D（P＜0.01）.The concentrations of serum LDH of group A were significantly increased than that of group B and D,and higher than that of group C at 10hrs and 24hrs post burns（P＜0.01）.Serum levels of LDH of group C were markedly higher than that of group B and D（P＜0.01）.Mitochondria damages with swelling,vacuolelike changes,and disappearance of carina following hydrofluoric acid and large area burned injury were observed.（Conclusion: The） injuries of the liver indicted by AST,ALT,LDH and the ultrastructure of mitochondria were more seriously post hydrofluoric acid burned injury than those were injured only by hot water. hydrofluoric acid;burns;liver