Research of antitumor effect of gene gun-mediated DNA vaccine pVAX1-2PFcGB immunization in Balb/c mice

Objective:To observe the inhibitory effect of fusion gene DNA vaccine pVAX1-2PFcGB immunization with gene gun approaching to subsequent tumor in Balb/c mice.Methods: The Balb/c mice were inoculated with EMT6 cells deriving from Balb/c mice breast cancer and immunized with DNA vaccine pVAX1-2PFcGB by gene gun.The inhibitory effect of DNA vaccine by observing the forming time、volume of tumour and inhibition ratio of tumour were studied.Results: Tumor growth was reduced dramatically.Conclusion: Gene gun-mediated DNA vaccine pVAX1-2PFcGB immunization can induce immunologic response.It is effective and practicable in inhibiting tumor growth.