Cryopreserved fetal liver transplantation(CFLT)in a child with acute leukemia
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Peng Yuyun,
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Yao Shanqian,
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Liu Haichuan,
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Lu:Shangen,
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Wang Yuezeng,
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Ceng Tiwen,
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Liu Jinghan,
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Wang Lianyuan,
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Liu Zuobin,
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Xu Yiqing,
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Wei Handong,
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Xing Guichun
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Abstract
In this article,a 6-year-old girl with APL(Aeute Promyeloeyte Leukemia,ANLL-M3)who has been transplanted with cryopreserved fetal liver cells(CFLC)(14.18×108/kg)from 6 Iivers of 16—24 week-old boy fetus in July 1986,alter a conditioning regimen CY 50mg/kg×2,DNR 20mg,TBI 5.1GY(0.05GY/min),is reported.Her hemopoiesis and immunity recovered in d 39. Since d 14,there was definite evidence of engraftment by the presence of the Y chromosomes from those boy donors’ fetus from 4% down to 2%,on d 35 the XY/XX chimeras remained to be 2%.To our knowledge,this is the first case of CFLT successfully performd in our country.
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