Effect of water extract from european vebena on tumor and immunological function of tumor-bearing mice

Objective To study the effect of water extract from European vebena on tumor and immunological functions of tumor-bearing H22 mice. Methods The mice were divided into control and cisplatin groups. The mice were given water extract from European vebena（32g/Kg） by gavage. Body weight,tumor weight,spleen weight,DTH,and HA were measured. Results The tumor weight and body weight were significantly lower in mice after treatment with water extract from European verbena and chemotherapy plus water extract from European verbena than in controls. The tumor inhibitory rate was 40.3% and 44.8%,respectively. The spleen index,DTH and HA were lower in mice after treatment with water extract from European verbena plus chemotherapy than in control and cisplatin groups. Conclusion Extract from European vebena inhibits tumor growth and reduce body weight,but does not impair the immunological function of tumor-bearing H22 mice. The immunological function is remarkably impaired when the extract is used in combination with chemotherapy.