Observation of reperfusion injury during cardiopulmonary bypass in man

To observe the changes of surgical reperfusion injury, plasma malonyl dialdehyde （MDA）, dienes with conjugated double bond （DCDB）, whole blood superxide dismutase （SOD） activity and plasma manganese-containing SOD （Mn-SOD） activity were determined during cardiopulmonary bypass （CPB） in 5 cases undergoing cardiosurgery. The results showed that reperfusion period on CPB was associated with a significant increase in the products of lipid peroxidation, MDA and DCDB （P＜0.05 for each）. However, it indicated that SOD of suppressed superoxide anion fell significantly （P＜0.05）. Of interest was the finding that plasema Mn-SOD activity rose significantly （P＜0.05） during reperfusion period.