The study on the susceptible gene of isoniazid and rifampicin-induced hepatotoxicity of pulmonary tuberculosis patients

Objective: To investigate the relationship between the susceptibility of isoniazid and rifampicin-induced hepatotoxicity and the N-acetyltransferase 2（NAT2） genotype in the tuberculosis patients. Methods: NAT2 gene was analyzed in 67 pulmonary tuberculosis patients who had normal or abnormal hepatic function by PCR-RFLP. Results: The frequencies of NAT2 gene mutation at codon 857 in patient group and control group were 20.3% and 7.1%,respectively,there were significant difference. Conclusion: NAT2 gene mutation at codon 857 might be one of susceptible genotype in the tuberculosis patients whose hepatic functions were abnormal.