Effect of IL-6 intervention on expressions of SAA in 3T3-L1 adipocytes

Objective To investigate the effect of IL-6 intervention on SAA expression in 3T3-L1 adipocytes. Methods 3T3-L1 adipocytes were incubated with IL-6 at different concentrations（0.1ng/ml,1ng/ml,10ng/ml）for different periods of time（6,12 and 24h）.SAA expression in different groups was detected by ELISA. Results IL-6 significantly increased the expression of SAA in 3T3-L1 adipocytes in a dose-and time-dependent manner. Conclusion IL-6 participates in insulin resistance and formation of vascular complication by stimulating SAA expression and secretion in 3T3-L1 adipocytes.