Study on the stability of complexes of levofloxacin and other five drugs by HPLC

Objective: To study the stability of complexes of levofloxacin hydruchloride and glucose injection and other five drugs at 25℃.Metheds: The samples of the complexes were collected at the 2,4,6、8、24hafter mixing levofloxacin hydruchloride and glucose injection and other five drugs at 25℃, the contents of levofloxacin hydruchloride and glucose injection and the drugs were determined by means of HPLC. The particles and pH of the samples were also determined.Results: There were no visible sign of incompatibility in the complexes, The pH and particles of solutions, varied slightly in acceptable range. The contents of levofloxacin hydruchloride and glucose injection and three other tested drugs more than 90% of their initial levels, while the contents of of the two tested drugs lower than 90% of their initial levels.Conclusion: Levofloxacin hydruchloride and glucose injection and five other drugs were compatible,the contents of levofloxacin hydruchloride and glucose injection was stable under the experiment condition.