Establishment of experimental model of acute heart failure in dogs with open abdominal injury induced by sea water immersion

Objective To establish an experimental model of acute heart failure（AHF）in dogs with open abdominal injury induced by sea water immersion. Methods Twenty-three healthy adult dogs were divided into open abdominal injury group（n=15）as group A and AHF model group n=8)as group B.After 0.5,1 and 2h of sea water immersion in group A,AHF was induced,and hemodynamic change in groups A and B was detected by sonography and BNP. Results AHF was induced in 8 dogs（53.3%）in group A.After sea water immersion,the heart rate,SBP,SDP,MAP,CVP were significantly higher in group A than in group B.Two hours after sea water immersion,the PAWP was 25±2.3mmHg,and the CO was 46.67%and 48.39%in group A,which were higher than those in group B（P＜0.01）.The levels of LVEDV,LVESV,SV,and LVEF were significantly higher in group A than in group B（P＜0.05）.The BNP was 622.77±52.21pg/mL in group A,which was increased by 441.6%compared with before injury and was 302.8% higher than in group B（P＜0.001）. Conclusion Open abdominal injury induced by sea water immersion can be used to establish the model of AHF.