To investigate the relationship between fibrinolysis and clinical parameters in patients with different degrees of hepatocirrhosis

Objective: To Investigate the relationship between hyperfibrionlysis and tissue plasminogen activator antigen（t-PA）,plasminogen activator inhibitor activity（PAI） in patients with different degrees of hepatocirrhosis associated with viral hepatitis.Methods: Eighty-six patients with cirrhosis were divided into three subgroups（A,B,and C） on the basis of Child-Pugh classification.Tissue plasminogen activator antigen（t-PA）,plasminogen activator inhibitor activity（PAI）,fibrin/fibrinogen degradation products（FDP）,and fragment D-dimer were measured in each patients.Results: t-PA antigen was incresed with the grade of cirrhosis in hyperfibrinolysis patient（P＜0.05）.t-PA and PAI activity had no significant changes in patients between hyperfibrionlysis and normal fibrionlysis.Conclusion: t-PA is a important biomarker in cirrhosis patient with hyperfibronlysis to estimate the grade of cirrhosis.