Short-term therapeutic effect and safety of combined benazepril and lercanidipine for mild-moderate hypertension

Objective To observe the short-term therapeutic effect and safety of combined benazepril and lercanidipine for mild-moderate hypertension. Methods One hundred and one patients with mild-moderate hypertension were randomly divided into group A and group B.Four weeks after patients in group A were treated with combined benazepril（10mg/d） and lercanidipine（10mg/d） and those in group B were treated with benazepril（10mg/d） alone,benazepril was increased to 20mg/d for those with their DBP at sitting≥90mmHg for 8 weeks.Then,their blood pressure reduction,curative effect and adverse reaction were assessed 1,4 and 8 weeks after treatment with combined benazepril and lercanidipine. Results The DBP in two groups at sitting was lower after 1,4 and 8 weeks of treatment with combined benazepril and lercanidipine than before treatment.The systolic and diastolic pressure at sitting was（133.72±11.87）mmHg and（80.11±8.77）mmHg respectively in group A,and（142.04±12.34）mmHg and（87.56±9.88）mmHg respectively in group B（P＜0.05）,with a total effective rate of 89.1% in group A and 67.0% in group B after 8 weeks of treatment（P＜0.05）.No significant difference was observed in adverse reaction between the two groups. Conclusion Combined benazepril and lercanidipine can decrease the blood pressure and increase the therapeutic effect for hypertension with no significant adverse reactions.