The protective effects of SIN-1, a kind of nitric oxide donor, on visceral blood supply in burnt rats

Objective: To evaluate the effects of exogenous NO supplement on visceral blood supply postburn.Methods: By use of a 30% TBSA Ⅲ degree burnt rat model, we observed the changes of renal or hepatic blood flow, artery blood analysis, visceral water contents after the supplement of SIN-1, a kind of nitric oxide donor. Results: There was obvious deficiency of blood supply in viscera postburn. Administration of SIN-1, without affecting the arterial blood pressure, could revert the decrease of pH, PaO₂, renal or hepatic blood flow to some extent reduce the water contents of heart, liver, lung, kidney postburn. Conclusion: The relative deficiency of nitric oxide in the early stage postburn in rat contribute to the decrease of blood suupply in viscera.