The study of p16 protein expression in non-small cell lung cancers

Objective: To study p16 expression in non-small cell lung cancers（NSCLC）. Methods: 40 NSCLC and its surrounding normal lung tissure were chosed to study the p16 expression with the method of immunohistochemistry. Results: Obviouse difference of p16 expression was found between NSCLC and normal lung tissure （P＜0.01）.There was no difference of p16 expression between subtypes of NSCLC（P ＞ 0.01）.The p16 expression of Low differenciate squamouse cell Ca was much lower than that of high and middle ones（P＜0.01）, the p16 expression of Low differenciate adenocarcinoma was much lower than that of high and middle ones（P＜0.01）. Conclusion: The p16 protein expression of NSCLC was much lower than that of normal lung tissure.