Investigation of urinary prosaglandin and plasma ANP in chronic renal failure

Urinary thromboxane B₂（TXB₂）and 6-keto-PGF₁α as well as plasma atrial natriuretic polypeptide（ANP）in 20 healthy volunteers and 13 patients suffering from chronic renal failure were measured with radioimmune assay.TXB₂ and 6-keto-PGF₁α were markedly lower than the normal values（p＜0.01）.There was,however,a close negative correlatino between urinary TXB₂ and plasma ANP（r=-0.61,p＜0.01）and between urinary 6-keto-PGF₁₂ and plasma ANP（r= -0.54,p＜0.05）Obviously,these data suggested that some of PGs are less synthesised or excresed in kidneys during renal failure meanwhile the heart and the kidneys coordinate each other well to maintain the hemeostasis of body.