The neuroprotective effects of Fasudilon cerebral ischemia-reperfusion injury on rats

Objective: Investigate the neuroprotective effects of Fasudil on cerebral ischemia-reperfusion injury. Methods: Animal models of reformed middle cerebral artery occlusion were made in80SD rats,treated by Fasudil or normal saline 30 minutes before the ischemia event,then recorded the regional blood flow of the ischemia tissue5min,60min after ischemia,and 30min after reperfusion;neurological outcome after 3-hour,24-hour,and 48-hour periods;the amount of lactic acid in ischemia area60min after ischimia,20,60and 120minutes after reperfusion. Results: The rCBF was higher in the Fasudil group than in the control group;the tissue content of lactic acid was less in the Fasudil group 60 and 120min after reperfusion. Conclusion: Fasudil increases rCBF of the ischemia area,accelerates removing of lactic acid,effectively protects brain tissue.