Biodistribution of ¹¹C-podophyllotoxin in murine model of lung carcinoma

Objective To investigate the biodistribution of ¹¹C-podophyllotoxin （¹¹C-PDT） in a murine model of lung carcinoma. Methods Mice bearing lung carcinoma were randomly divided into three groups according to the injection time of ¹¹C-PDT. Biodistribution of ¹¹C-PDT in mice was detected with a well-gamma detector 15, 30, and 60min after ¹¹C-PDT injection from the tail vein. Results The distribution of ¹¹C-PDT radioactivity was the highest in kidneys. A considerable radioactive uptake was observed in the tumor. However, the tumor/muscle ratio was rather high 60min after ¹¹C-PDT injection. Conclusion ¹¹C-PDT can be used as a promising PET tracer for lung carcinoma.